Drugs reducing gastric acid secretion

DRUGS REDUCING GASTRICACID SECRETION…• ….H2 RECEPTOR ANTAGONISTMechanism Of Action (MOA):• Inhibit action of histamine on the H2 receptor of the parietal cells, reducing gastric acidoutput and concentration.• Cimetidine, Ranitidine, Famotidine, NizatidineCIMETIDINEIndication:• Duodenal and gastric ulcer• Short bowel ulcer (small intestine ulcer)Contraindication:• Lactation• Gastro-esophageal reflux disease (GERD)(digestivedisorder that affects the lower esophageal sphincter)• Pregnancy• Zollinger-Ellison Syndrome (gastrin-secreting tumor orhyperplasia of islet cells in the pancreas causesoverproduction of gastric acid)• Hypersensitivity• Special precaution should be taken in impaired renal functionCIMETIDINEDose:• Oral: 400 mg BD or 800 mgoD before bed for 4-8 weeks• IV: 300 mg slow IV given over2 minutes(Repeated 6-8 hourlyas required)Adverse Reaction:• Diarrhea• Somnolence (sleepiness)• Jaundice• Dizziness/Headache• Pancreatitis• Gynaecomastia (enlargement of man’s breast)• Granulocytopenia (↓peripheral blood granulocytes)• Arthralgia (joint pain)• Hepatitis• Alopecia• Blood dyscrasiasCIMETIDINENursing Considerations:• Dosage adjustment is needed in patients with renal impairment.• Instruct the patient to take the drug as advised, even after the pain subsides to ensure proper healing.• Tell patient to swallow the drug with water and … Purchase document to see full attachment

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